Questions about Regennew procedures?

Top Questions

How do I get started?

The best way to get started is to either write to our WhatsApp, call free to our Center at 0090 850 811 9660, reach us from our social media directly. You can also start the process by completing the Regennew Candidate Form on our website. This will give you initial information on setting up a patient evaluation or a phone review of your condition with a doctor.

Multiple Areas Treated – Can you treat more than one area at a time?

This is on a case-by-case basis and although we have before, it would be at the advice of the doctor to treat more than one area. One of the many things that set Regennew procedures apart from all other stem cell therapy being offered is treat two knees or shoulders at the same. Click here to learn about conditions treated.

What are the next steps if I’m interested?

Call us at 0090 850811 9660 to schedule a phone review of your images with one of our doctors or schedule an appointment.

Does my age make a difference?

Our registry based research has shown that, for stem cell procedures, older age does not adversely impact outcome. Complete the Regennew Candidate Form to arrange a patient evaluation or a phone review of your condition with a doctor.

What is the post-injection rehab like?

That depends on which procedure is performed. For example, for knee arthritis, you can expect 3 days of significant down-time followed by a slow return to normal activities over 4-6 weeks.

What is the difference between a same day adipose derived stem cell injection and a cultured stem cell injection?

The procedure involves taking  cells from adipose tissue and  then injecting to the injured area on the same day.

The cultured procedure grows those cells to larger numbers over a period of a few weeks.

If I can’t expect a new knee from a stem cell treatment for severe arthritis, how does this work?

Many mechanisms have been put forth, including long-term blocking of cells that destroy the joint, rescue of cells that fix the joint, and replacing lost native stem cells that maintain the joint.

If I have severe arthritis, will a stem cell injection regrow my cartilage back?

While we have seen MRI evidence of cartilage growth in mild and moderate arthritis, we generally don’t see it with severe arthritis.

However usage of adipose derived stem cells for your injury supports better than bone marrow derived cells, you should not expect full cartilage growth with severe arthritis.

Do you have any statistics on patient outcomes or success rates?

We do. We have been collecting patient outcome data for quite some time and we regularly and openly publish the results with the public.

Are Regennew Network Doctors all the Same?

All physicians in the Regennew network are orthopedic surgeons and have thousands of hours experience of orthopedic threatments.

Price / Cost: How much do Regennew procedures cost?

Because the procedure protocol will vary from person to person and each person will have a unique condition to be treated, the pricing of procedures can vary considerably from patient to patient. An evaluation will give you a better idea of condition, treatment, and costs specific to your condition. There will not be an additional consultation fee for the initial face to face consult.

What types of conditions can be treated?

Select the body part you are interested in from the image on the right. Although this is not a complete list, it will provide the most common treatments by body part.

If you have a question about whether your condition can be treated, please call us at 0090 850 811 9660

Are the Regennew procedures covered by insurance?

No, these procedures are too new to be covered yet. Don’t let someone fool you, PRP and stem cell injections have no insurance coverage at this time.

Some health insurance plans may cover the initial evaluation. If your plan does,  we will bill the carrier. There is not a consultation fee for the initial face to face consult.

We recommend that you contact your insurance carrier for more information about your specific coverage details.

Is a Stem Cell Procedure the same as PRP (Platelet Rich Plasma)?

No. PRP is concentrating platelets in the blood, not stem cell therapy. This is a more detailed discussion on the differences between PRP and stem cell therapy.

We do offer the Platelet Rich Plasma Procedure, which is a platelet procedure that is quite different from the bloody PRP commonly available using bedside centrifuges. To see a patient infographic on these differences, see this link for general info on the Regennew platelet procedure and this one for a comparison between our process and typical bedside PRP machines.

How is the Regennew Stem Cell Procedure different from other stem cell procedures currently being offered for orthopedic conditions?

Some clinics are beginning to offer basic cell therapies, most in plastic surgery and cosmetics, with a few clinics starting to try orthopedic therapies. While we welcome the growth in cell-based medicine, we also know that we’re market leader in our area. As leader, we set a higher standard for ourselves in all of the cell-based procedures we offer our patients.

General

What if I have anemia?

If your hematocrit is below 30 or your hemoglobin is below 10, we may not be able to perform the procedure. If your hematocrit is between 30-36 or hemoglobin below 12, we may follow-up your condition with your family doctor.

How long has Regennew been doing these procedures?

Stem Cell procedures conducted clinical trials starting from 2000 – 2007, which were the first orthopedic stem cell procedures performed. Regennew has performed Adipose Derived Stem Cell  Single-Day procedure that is currently performed was developed in 2011 and has been continually improved since that time.

Are these embryonic stem cells?

No, they are simply your own adult stem cells. We only use autologous (your own) cells.

Are umbilical cord stem cells better than adult stem cells?

Cord stem cells are stem cells isolated from a baby’s umbilical cord. While they may be more biologically active because of their young age, recent research has suggested that they can also transmit genetic diseases that the baby may carry. Until these issues are further sorted out (likely with better genetic testing), we would advise against using any donor stem cells to treat non-life threatening disease. (cells from another person). This would include cord cells, embryonic stem cells, or someone else’s adult stem cells.

Are there different types of adult stem cells?

Yes, there are many types of adult stem cells. The type of adult stem cell that is most often seen in research as being associated with orthopedic tissue repair is a Adipose Derived Stem Cells (ADSC). ADSCs generally be harvested from fat tissiue. Adipose tissue contains many also MSCs, Adipose Derived Stem Cells usage is better than mesenchymal stem cells.

What are there different types of Mesenchymal Stem Cells (MSC’s)?

For orthopedic applications, two main types of MSCs have been used, adipose (fat) derived and bone marrow derived. ADSCs is derived from adipose tissue (fat). This can be obtained via lipoaspiration. Bone marrow SCs are taken via a needle through a bone marrow aspirate. For orthopedic applications, Adipose derived SCs consistently and dramatically higher perform than bone marrow derived cells. In studies of cartilage repair, bone repair, and soft-tissue repair, Adipose derived Stem Cells are much more adept at these tasks. This makes sense, as they perform this function naturally (homologous) everyday. In addition, for surgical micro fracture to repair small amounts of knee cartilage damage, it’s Adipose Derived Stem Cell’s that are released to do that job.

Doesn’t adipose (fat tissue) have more stem cells than bone marrow?

Yes. Estimated number of stem cells in processed fat is higher. This is a good hard core science review of the kits often used by physicians which estimate these numbers. Basically, what physicians believe to be cells are actually small globs of adipose tissue. Second, the proprietary Regennew stem cell isolation method dramatically increases the number of stem cells isolated from Adipose.

Still, on a weight to weight basis, adipose can contain more mesenchymal stem cells than bone marrow, which work as well for orthopedic applications. In addition, in the Regennew procedure we offer the best.

X-Ray vs. MRI

Because an X-ray will only show the condition of the bone, not the soft tissue, the doctor needs an MRI to accurately evaluate the condition of the whole area

The doctor will need the most recent MRI available. The MRI should be without contrast and less than two years old. If you’ve had surgery or a scope done since having the MRI, we would need an MRI that was taken after the operation/procedure.

What triggers the cessation of cell growth during regeneration? Has regeneration ever surpassed expected optimal growth?

Stem cells will stop proliferating when they physically contact each other. Culturing these cells, shows that once they reach that point, they refuse to continue to grow (proliferate). This is because they are repair cells and when an area in need of repair is fully covered, they get the signal to stop growing. In patients where we have ongoing MRI surveillance of the re-implant sites, there has been no evidence of overgrowth where the regeneration has surpassed “expected optimal growth”.

How will my stem cells know when to stop growing?

Unlike embryonic stem cells, adult stem cells do not generally keep growing, even in culture. For example, most patients whose stem cells we grow to bigger numbers in the lab will lose their ability for continued cell growth after just a few weeks. In addition, the same body signals that would tell these cells to stop growing in healing a normal fracture or ligament tear are still present in your body.

Do stem cells stay localized to the injection site? Is there any risk of them traveling throughout the body?

Stem Cells do stay localized to the injection site across multiple studies. This is likely linked to the fact that they generally do not circulate in the bloodstream like other adult stem cell types and are primarily found resident in the tissues they serve.

Safety & Compliance

What if I take Coumadin, Plavix, or other blood thinners?

We generally recommend that you stop these before the procedure. For example, if you take Coumadin, you need to have the OK of your family doctor or cardiologist to come off this drug and an INR (blood clotting test) that is in the normal range before pursuing this procedure. If you take other blood thinners such as Plavix, you should be off this drug for 72 hours prior to the procedure. Your family doctor or cardiologist may also need to be consulted to ensure that it’s safe to come off of this medication. If you take a daily baby aspirin, then you need to come off this one week before the procedure.

What if I have a blood clotting disorder?

If your clotting times are normalized by taking clotting factors, then there should be no problem performing the procedure.

What has been the longest time period of observation that leads you to conclude there is no tumor risk?

More than 20 years.

What complications have been experienced with the procedures?

Using the guidelines for complications reporting, our complications to date have been in the mild category and rare. This means that either the complication (like transient swelling) required no medical treatment (Mild), or if it did require medical treatment, the treatment was simple (Moderate-like a patient who failed the procedure who ultimately decided to get the knee replacement that he or she was planning before the procedure). There is  published (to date) safety and complications tracking study of adult stem cell use in patients. This study did not show any serious stem cell related complications and it did not show that any patient developed a stem cell-related cancer. In addition, most recent safety paper was named the best of its type by a meta-analysis that appeared in the prestigious medical journal, Osteoarthritis, and Cartilage.

You can View the safety data from medical journals and press open to public  from internet.

Is a fat lipoaspiration safer than a bone marrow aspirate?

Yes, an analysis of published research shows that  bone arrow aspiration is riskier than lipoaspiration. You can find more information on this at research pages and / or results of studies published.

Can an adult stem cell re-implant cause cancer?

The basic science on adult stem cells shows that if the cells are kept in culture for short periods, there is no risk of the cells becoming cancerous. There are published (to date) safety and complications tracking study of adult stem cell use in patients. This study did not show any serious stem cell related complications and it did not show that any patient developed a stem cell-related cancer. Finally, we have seen no evidence of significant complications at these re-implant sites. We also work with an outside lab for quality to clear each patient’s cells before they are used in treatment as an additional safety check.

Regennew is proud of its history of regulatory compliance and is deeply familiar with the regulatory environment in which it operates.

Medications

Why can’t I be on certain medications during the procedure?

Certain types of medications will negatively impact the stem cells. In addition, we generally see that many prescription medications will reduce stem cell number.

What if I take Coumadin, Plavix, or other blood thinners?

We generally recommend that you stop these before the procedure. For example, if you take Coumadin, you need to have the OK of your family doctor or cardiologist to come off this drug and an INR (blood clotting test) that is in the normal range before pursuing this procedure. If you take other blood thinners such as Plavix, you should be off this drug for 72 hours prior to the procedure. Your family doctor or cardiologist may also need to be consulted to ensure that it’s safe to come off of this medication. If you take a daily baby aspirin, then you need to come off this one week before the procedure.

What if I have a blood clotting disorder?

If your clotting times are normalized by taking clotting factors, then there should be no problem performing the procedure.

Are there any medications or supplements I can take that will increase the activity or healing abilities of my stem cells?

Our physicians propose Formula to support healthy cartilage production up to your situation. Please directly ask your physician after your implementation about medication or supplements.

Effectiveness / Outcomes

What basic science or published clinical data exist that show that these concentrated stem cells can help heal orthopedic injuries?

Stem cell procedures have been studied extensively for more than a decade and patients are part of the stem cell re-implantation database for orthopedic purposes. There are regularly publish outcome data from patient registry and they are available to the public.

Can a Second Procedure Be Helpful?

Most of the patients do not need more than one procedure. Our analysis of patients who have had a second procedure shows that very often a second procedure can help continue and improve the success a patient has from our regenerative treatments.

Insurance / Coverage

Are the Regennew procedures covered by insurance?

No, these procedures are too new to be covered yet. Don’t let someone fool you, PRP and stem cell injections have no insurance coverage at this time.

Some health insurance plans may cover the initial evaluation. If your plan does, and we are part of your insurance carrier network, we will bill the carrier. There will not be a consultation fee for the initial face to face consult.

We recommend that you contact your insurance carrier for more information about your specific coverage details.

Locations

Where Can I Get a Regennew® Procedure?

We’ve been working hard for several years growing our provider network and are continuously training doctors to perform the Regennew procedures. We have very high standards for our network doctors and are extremely selective in allowing doctors to join the network.

Phone review of your condition

While we prefer to see someone in person to review their condition and evaluate whether they would be a good candidate for Regennew, many of our network doctors offer an initial phone review of your condition.

The doctor can look at your films, history, and speak to you on the phone about whether he or she believes this may help your problem. It’s important to note that this is not the formation of a traditional doctor-patient relationship until you actually visit the doctor. Rather, this is just an opportunity for the doctor to determine if you’re a reasonable candidate for the procedure and for you to ask additional questions.

The doctor will require an MRI on CD / DVD or an uploaded version of your MRI to our web site’s related page in order to review your imaging. Check with us on how to deliver your MRI to them.

There is no  charge for phone reviews with a Regennew doctor.

Procedure – What to expect

When can I expect to feel better?

The results should become apparent over 1-3 months but sometimes can take as long as 4-6 months.

What happens to the stem cells after you take them out?

The cells are isolated in the lab. For the Single Day procedure, this isolated stem cell fraction is placed right back into the body.

How painful is the procedure for implanting stem cells?

About as painful as a typical shot in a doctor’s office.

How long do I have to stay for the procedure?

There is virtually no hospitalisation with this outpatient procedure. The entire process will take only one days depending on the doctor’s recommendation. You can walk right out of the clinic the single day any procedure is completed. For all procedures you will only need to come in for one day for treatment.

How do you know where to place the cells?

We use real-time x-ray known as fluoroscopy or musculoskeletal ultrasound. Your MRI images are used to help plan that injection.

Do I need to have someone drive me?

All of our patients walk out of the clinic. However, having someone drive you for a medical procedure is never a bad idea. so you should consult with your doctor or clinic about your specific treatment and protocol to ensure that it will be safe for you to drive if you wish to do so. We are providing transfers to your hotel to clinic and back by our agreed agency. Our contracted tourism agency will arange you transfers to and from clinic during your hotel reservation process.

Recovery / Post-Procedure

Will I need a second procedure?

Most patients get a single procedure.

Some of our patients will require a second or even third procedure.

When can I return to normal activity?

This depends on the type of procedure. However, all of our procedures are designed to promote as much early activity as possible. Here is a general guide:

If there is more minimal cartilage loss, low impact activities would be encouraged immediately after the procedure. Full high impact activities would be expected at 4-6 weeks.

Should I take specific supplements after my procedure?

Yes, Our phsicians may propose you supplements based on your case and implementaion.

Is physical therapy needed after the procedure?

In general, we always try to look at more than one injured part. As a result, it’s very likely we will recommend other types of conservative care to restore normal biomechanics. This might include physical therapy, different types of myofascial release, or specific home exercises.

Conditions Treated / Not Treated

What types of conditions can be treated?

Click here to choose the body part that you are interested in. While this is not a complete list, it will provide you with the most common treatments by body part.

If you have a question about whether your condition can be treated, please call us at 0090 850 811 9660, send a note to us via whatsapp, e-mail, use social media or contact your local Regennew Agent.

How is the Regennew Stem Cell Procedure different from other stem cell procedures currently being offered for orthopedic conditions?

When we first began offering orthopedic stem cell therapy we were one of the few clinics in the world treating orthopedic problems with stem cells. Now other clinics are beginning to offer basic cell therapies, most in plastic surgery and cosmetics, with a few clinics just starting to try orthopedic therapies. While we welcome the growth in cell-based medicine, we also know that we’re one of the leader in our area. As a leader, we set a higher standard for ourselves in all of the cell-based procedures we offer our patients.

Pricing / Cost

Price / Cost: How much do Regennew procedures cost?

Because the procedure protocol will vary from person to person and because each person will have a unique condition to be treated, the pricing of procedures can vary considerably from patient to patient. An evaluation will give you a better idea of condition, treatment, and costs specific to your condition.

Is Regennew Right For You?